Tianeptine: Uses, Risks, and Safety Information

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Tianeptine: Uses, Risks, and Safety Information

Tianeptine is a prescription medication used primarily for treating depression in some European, Asian, and Latin American countries. However, it is not approved for medical use in the United States due to safety concerns and its potential for misuse and dependence.

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Overview

Tianeptine influences brain chemicals and is known to improve mood at low doses. However, at higher doses, it acts on the brain’s opioid receptors, increasing the risk of addiction, serious side effects, and withdrawal symptoms.

Approved Uses

• Depression:
  Tianeptine is possibly effective for managing depression. Studies suggest it may be as effective as other commonly prescribed antidepressants.

Unproven Uses

While tianeptine is sometimes used for conditions like:

• Pain management

• Anxiety

• Asthma

There is insufficient scientific evidence to support its effectiveness for these uses.

Safety and Side Effects

General Risk

When taken by mouth, tianeptine is considered possibly unsafe. High doses or long-term use can lead to:

• Drowsiness

• Confusion

• Breathing difficulties

• Coma

• Death

• Dependence and withdrawal symptoms

Special Warnings

• Pregnancy: Possibly unsafe. Tianeptine use during pregnancy may cause the newborn to be dependent on the drug.

• Breastfeeding: Insufficient safety data. Similar drugs are known to pass into breast milk.

• History of Substance Abuse: Increased risk of dependence and misuse.

• Before Surgery: Tianeptine can intensify sedative effects. Discontinue use at least two weeks before any surgical procedures.

Drug Interactions

Major Interaction – Avoid Combination

• Antidepressants (MAOIs): Combining tianeptine with MAOIs such as phenelzine (Nardil), selegiline (Zelapar), or tranylcypromine (Parnate) can lead to serious side effects.

Moderate Interactions – Use with Caution

• Alcohol: May slow the breakdown of tianeptine, increasing its levels and risk of toxicity.

• Aspirin: Long-term use may raise tianeptine levels, increasing the risk of side effects.

• Sedative Medications (CNS Depressants): Combined use may lead to excessive drowsiness or dangerous breathing problems.

Availability and Regulation

Tianeptine is prescription-only in some countries and is not approved for use in the United States. It is listed on the U.S. Food and Drug Administration (FDA) Advisory List of ingredients that are prohibited in dietary supplements.

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Key Takeaway

While tianeptine may be helpful for depression under medical supervision in certain countries, its potential for addiction, misuse, and severe health risks makes it unsafe for unsupervised use. It is not recommended or approved for use in the U.S.

Always consult with a qualified healthcare professional before considering or using medications like tianeptine, especially if you have underlying health conditions or are taking other medications.